The Association between Prebiotic Fiber Supplement Use and Colorectal Cancer Risk and Mortality in the Women's Health Initiative.

ABSTRACT:

Background

Fiber-based prebiotic supplements are marketed for maintaining bowel health and promoting beneficial gut bacteria. However, the association between prebiotic supplement use and colorectal cancer risk and mortality is unknown.

Methods

The association between prebiotic use and colorectal cancer risk and mortality was evaluated in postmenopausal women in the Women's Health Initiative study. Self-reported prebiotic use was documented at study enrollment. Adjudicated colorectal cancer cases and mortality were captured using medical and death records. Cox proportional hazards models were used to estimate the HR related to prebiotic use and colorectal cancer risk and mortality.

Results

In total, 3,032 colorectal cancer cases were diagnosed during an average 15.4 y

SUBMITTER: Skiba MB 

PROVIDER: S-EPMC6825571 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature