Differences in Genome-wide DNA Methylation Profiles in Breast Milk by Race and Lactation Duration.

ABSTRACT: Black women in the United States are disproportionately affected by early-onset, triple-negative breast cancer. DNA methylation has shown differences by race in healthy and tumor breast tissues. We examined associations between genome-wide DNA methylation levels in breast milk and breast cancer risk factors, including race, to explain how this reproductive stage influences a woman's risk for, and potentially contributes to racial disparities in, breast cancer. Breast milk samples and demographic, behavioral, and reproductive data, were obtained from cancer-free, uniparous, and lactating U.S. black (n = 57) and white (n = 82) women, ages 19-44. Genome-wide DNA methylation analysis was performed on extracted breast milk DNA using the Infinium HumanMethylation450 BeadChip. Stati

SUBMITTER: Davis Lynn BC 

PROVIDER: S-EPMC6825576 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature