Association of Viral Suppression With Lower AIDS-Defining and Non-AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study.

ABSTRACT:

Background

Viral suppression is a primary marker of HIV treatment success. Persons with HIV are at increased risk for AIDS-defining cancer (ADC) and several types of non-AIDS-defining cancer (NADC), some of which are caused by oncogenic viruses.

Objective

To determine whether viral suppression is associated with decreased cancer risk.

Design

Prospective cohort.

Setting

Department of Veterans Affairs.

Participants

HIV-positive veterans (n = 42 441) and demographically matched uninfected veterans (n = 104 712) from 1999 to 2015.

Measurements

Standardized cancer incidence rates and Poisson regression rate ratios (RRs; HIV-positive vs. uninfected persons) by viral suppression status (unsuppressed: person-time with HIV RNA levels ≥500 copies/mL; early

SUBMITTER: Park LS 

PROVIDER: S-EPMC6825799 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature