The genetic polymorphisms of ZC3HC1 and SMARCA4 are associated with hypertension risk.

ABSTRACT:

Aim

In this study, we aimed to evaluate the association between genetic variants of ZC3HC1 and SMARCA4 and hypertension risk in the Chinese Han population.

Methods

The Agena MassAssary platform was used to determine the genotypes of eight SNPs in ZC3HC1 and SMARCA4 from 350 hypertension patients and 483 healthy controls. Chi-squared tests and genetic model were used to evaluate the associations. Odds ratios and 95% confidence intervals were calculated using unconditional logistic regression. The statistical power of this study was estimated through the Power and Sample Size Calculation online software.

Result

In the genetic model analysis, we identified that the SNP of rs1464890 in ZC3HC1 was associated with a 0.68-fold decreased risk of hypertension in the codominant

SUBMITTER: Ma H 

PROVIDER: S-EPMC6825853 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature