Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.

ABSTRACT: The horse reference genome from the Thoroughbred mare Twilight has been available for a decade and, together with advances in genomics technologies, has led to unparalleled developments in equine genomics. At the core of this progress is the continuing improvement of the quality, contiguity and completeness of the reference genome, and its functional annotation. Recent achievements include the release of the next version of the reference genome (EquCab3.0) and generation of a reference sequence for the Y chromosome. Horse satellite-free centromeres provide unique models for mammalian centromere research. Despite extremely low genetic diversity of the Y chromosome, it has been possible to trace patrilines of breeds and pedigrees and show that Y variation was lost in the past approximately 2

SUBMITTER: Raudsepp T 

PROVIDER: S-EPMC6825885 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature