Neuroendocrine marker staining pattern categorization of small-sized pulmonary large cell neuroendocrine carcinoma.

ABSTRACT: BACKGROUND:The aim of this study was to identify subgroups with good or bad prognosis in patients with pulmonary large cell neuroendocrine carcinoma (LCNEC) based on immunostaining patterns with neuroendocrine markers and compare them with small cell lung carcinoma (SCLC). METHODS:From January 2001 to December 2017, of all patients with resected LCNEC and SCLC, we selected patients whose pathological tumor sizes were ≤30 mm in diameter (defined as small-sized tumors) and who underwent complete resection with lymphadenectomy. We classified patients with small-sized LCNEC (sLCNEC) into two subgroups based on immunostaining patterns with three neuroendocrine markers (chromogranin A, synaptophysin, and NCAM) and compared them to small-sized SCLC (sSCLC). RESULTS:A total of 48 patients with sLC

SUBMITTER: Minami K 

PROVIDER: S-EPMC6825905 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature