Integrated transcriptomics reveals master regulators of lung adenocarcinoma and novel repositioning of drug candidates.

ABSTRACT:

Background

Lung adenocarcinoma is the major cause of cancer-related deaths in the world. Given this, the importance of research on its pathophysiology and therapy remains a key health issue. To assist in this endeavor, recent oncology studies are adopting Systems Biology approaches and bioinformatics to analyze and understand omics data, bringing new insights about this disease and its treatment.

Methods

We used reverse engineering of transcriptomic data to reconstruct nontumorous lung reference networks, focusing on transcription factors (TFs) and their inferred target genes, referred as regulatory units or regulons. Afterwards, we used 13 case-control studies to identify TFs acting as master regulators of the disease and their regulatory units. Furthermore, the inferred ac

SUBMITTER: De Bastiani MA 

PROVIDER: S-EPMC6825976 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature