Defining fallopian tube-derived miRNA cancer signatures.

ABSTRACT:

Background

MicroRNAs have recently emerged as promising circulating biomarkers in diverse cancer types, including ovarian cancer. We utilized conditional, doxycycline-induced fallopian tube (FT)-derived cancer models to identify changes in miRNA expression in tumors and plasma, and further validated the murine findings in high-grade ovarian cancer patient samples.

Methods

We analyzed 566 biologically informative miRNAs in doxycycline-induced FT and metastatic tumors as well as plasma samples derived from murine models bearing inactivation of Brca, Tp53, and Pten genes. We identified miRNAs that showed a consistent pattern of dysregulated expression and validated our results in human patient serum samples.

Results

We identified six miRNAs that were significantly dysreg

SUBMITTER: Dejene SB 

PROVIDER: S-EPMC6825987 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature