MiR-106b-5p promotes aggressive progression of hepatocellular carcinoma via targeting RUNX3.

ABSTRACT:

Background and objectives

The roles of microRNA(miR)-106b-5p in hepatocellular carcinoma (HCC) remain unclear. We aimed here to investigate the clinical significance of miR-106b-5p expression in HCC and its underlying mechanisms.

Methods

Expression levels of miR-106b-5p in 108 HCC clinical samples by quantitative real-time reverse transcription PCR. Associations of miR-106b-5p expression with various clinicopathological features and patients' prognosis were evaluated by Chi-square test, Kaplan-Meier, and Cox proportional regression analyses, respectively. The target gene of miR-106b-5p and their functions in HCC cells were investigated by luciferase reporter, CCK-8, and Transwell Matrigel invasion assays.

Results

miR-106b-5p expression was markedly higher in HCC tissu

SUBMITTER: Gu H 

PROVIDER: S-EPMC6825988 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature