Molecular and mechanical signals determine morphogenesis of the cerebral hemispheres in the chicken embryo.

ABSTRACT: During embryonic development, the telecephalon undergoes extensive growth and cleaves into right and left cerebral hemispheres. Although molecular signals have been implicated in this process and linked to congenital abnormalities, few studies have examined the role of mechanical forces. In this study, we quantified morphology, cell proliferation and tissue growth in the forebrain of chicken embryos during Hamburger-Hamilton stages 17-21. By altering embryonic cerebrospinal fluid pressure during development, we found that neuroepithelial growth depends on not only chemical morphogen gradients but also mechanical feedback. Using these data, as well as published information on morphogen activity, we developed a chemomechanical growth law to mathematically describe growth of the neuroepitheli

SUBMITTER: Garcia KE 

PROVIDER: S-EPMC6826035 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature