Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung.

ABSTRACT: Alternatively activated macrophages are essential effector cells during type 2 immunity and tissue repair following helminth infections. We previously showed that Ym1, an alternative activation marker, can drive innate IL-1R-dependent neutrophil recruitment during infection with the lung-migrating nematode, Nippostrongylus brasiliensis, suggesting a potential role for the inflammasome in the IL-1-mediated innate response to infection. Although inflammasome proteins such as NLRP3 have important proinflammatory functions in macrophages, their role during type 2 responses and repair are less defined. We therefore infected Nlrp3 ^-/- mice with N. brasiliensis Unexpectedly, compared with wild-type (WT) mice, infected Nlrp3 ^-/- mice had increased

SUBMITTER: Chenery AL 

PROVIDER: S-EPMC6826118 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature