Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex.

ABSTRACT: Sleep abnormalities are common with aging. Studies show that sleep plays important roles in brain functions, and loss of sleep is associated with increased risks for neurological diseases. Here, we used RNA sequencing to explore effects of age on transcriptome changes between sleep and sleep deprivation (SD) in medial prefrontal cortex and found that transcriptional changes with sleep are attenuated in old. In particular, old mice showed a 30% reduction in the number of genes significantly altered between sleep/wake and, in general, had smaller magnitudes of changes in differentially expressed genes compared to young mice. Gene ontology analysis revealed differential age effects on certain pathways. Compared to young mice, many of the wake-active functions were similarly induced by SD in o

SUBMITTER: Guo X 

PROVIDER: S-EPMC6826131 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature