The Structural and Immunological Properties of Chimeric Proteins Containing HIV-1 MPER Sites.

ABSTRACT: The human immunodeficiency virus (HIV-1) poses a serious risk to global public health. The development of a safe and effective vaccine could stop the HIV/AIDS pandemic. Much of the research focused on HIV-1 prevention through vaccination is aimed at developing immunogens and immunization strategies to induce the formation of antibodies with neutralizing activity against a broad range of HIV-1 isolates (bNAbs). The objective of this study was to develop immunogens capable of targeting an immune response to MPER, one of the regions of bNAb binding in Env. Two immunogens carrying MPER fragments on their scaffolds (protein YkuJ Bacillus subtilis and artificial polypeptide TBI) were constructed. Circular dichroism spectroscopy was used to show that the secondary structure of the immunogens was

SUBMITTER: Rudometov AP 

PROVIDER: S-EPMC6826149 | biostudies-literature | 2019 Jul-Sep

REPOSITORIES: biostudies-literature