A human tissue-specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence.

ABSTRACT: Aging is the biggest risk factor for cancer, but the mechanisms linking these two processes remain unclear. Using GTEx and TCGA data, we compared genes differentially expressed with age and genes differentially expressed in cancer among nine human tissues. In most tissues, aging and cancer gene expression pattern changed in the opposite direction. The exception was thyroid and uterus, where we found transcriptomic changes in the same direction in aging and in their corresponding cancers. The overlapping sets between genes differentially expressed with age and genes differentially expressed in cancer across tissues were enriched for several processes, mainly cell cycle and the immune system. Moreover, cellular senescence signatures, derived from a meta-analysis, changed in the same directio

SUBMITTER: Chatsirisupachai K 

PROVIDER: S-EPMC6826163 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature