Inhibition of urinary stone disease by a multi-species bacterial network ensures healthy oxalate homeostasis.

ABSTRACT: The incidence of urinary stone disease is rapidly increasing, with oxalate being a primary constituent of approximately 80% of all kidney stones. Despite the high dietary exposure to oxalate by many individuals and its potential nephrotoxicity, mammals do not produce enzymes to metabolize this compound, instead relying in part on bacteria within the gut to reduce oxalate absorption and urinary excretion. While considerable research has focused on isolated species of oxalate-degrading bacteria, particularly those with an absolute requirement for oxalate, recent studies have pointed to broader roles for microbiota both in oxalate metabolism and inhibition of urinary stone disease. Here we examined gut microbiota from patients with and live-in individuals without urinary stone disease to dete

SUBMITTER: Miller AW 

PROVIDER: S-EPMC6826259 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature