β‑elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A‑VEGFA pathway based on network pharmacology.

ABSTRACT: Pancreatic cancer remains one of the most lethal types of cancer. Late‑stage pancreatic cancer patients usually suffer peritoneum effusion, which severely compromises quality of life. Great efforts have been made concerning the treatment of peritoneum effusion, including treatment with β‑elemene. Although peritoneal perfusion of β‑elemene attenuates the progression of malignant effusion without severe adverse effects in the clinic, the underlying molecular mechanism underlying the activity of β‑elemene against peritoneum effusion remains unclear. In the present study, a network pharmacology approach was undertaken to explore the mechanism of β‑elemene against peritoneum effusion. Particularly, the networks of β‑elemene and pancreatic cancer target genes were constructed based on the BATMAN

SUBMITTER: Zhu J 

PROVIDER: S-EPMC6826333 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature