P120 Catenin Isoforms Differentially Associate with Breast Cancer Invasion and Metastasis.

ABSTRACT: Tumor metastasis is the endpoint of tumor progression and depends on the ability of tumor cells to locally invade tissue, transit through the bloodstream and ultimately to colonize secondary organs at distant sites. P120 catenin (P120) has been implicated as an important regulator of metastatic dissemination because of its roles in cell-cell junctional stability, cytoskeletal dynamics, growth and survival. However, conflicting roles for P120 in different tumor models and steps of metastasis have been reported, and the understanding of P120 functions is confounded by the differential expression of P120 isoforms, which differ in N-terminal length, tissue localization and, likely, function. Here, we used in silico exon expression analyses, in vitro invasion assays and both RT-PCR and immunofl

SUBMITTER: Venhuizen JH 

PROVIDER: S-EPMC6826419 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature