Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization.

ABSTRACT: Autophagy is a tightly regulated catabolic process that facilitates nutrient recycling from damaged organelles and other cellular components through lysosomal degradation. Deregulation of this process has been associated with the development of several pathophysiological processes, such as cancer and neurodegenerative diseases. In cancer, autophagy has opposing roles, being either cytoprotective or cytotoxic. Thus, deciphering the role of autophagy in each tumor context is crucial. Moreover, autophagy has been shown to contribute to chemoresistance in some patients. In this regard, autophagy modulation has recently emerged as a promising therapeutic strategy for the treatment and chemosensitization of tumors, and has already demonstrated positive clinical results in patients. In this revie

SUBMITTER: Perez-Hernandez M 

PROVIDER: S-EPMC6826429 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature