Coordinated Activity of Transcriptional Networks Responding to the Pattern of Action Potential Firing in Neurons.

ABSTRACT: Transcriptional responses to the appropriate temporal pattern of action potential firing are essential for long-term adaption of neuronal properties to the functional activity of neural circuits and environmental experience. However, standard transcriptome analysis methods can be too limited in identifying critical aspects that coordinate temporal coding of action potential firing with transcriptome response. A Pearson correlation analysis was applied to determine how pairs of genes in the mouse dorsal root ganglion (DRG) neurons are coordinately expressed in response to stimulation producing the same number of action potentials by two different temporal patterns. Analysis of 4728 distinct gene-pairs related to calcium signaling, 435,711 pairs of transcription factors, 820 pairs of voltage

SUBMITTER: Iacobas DA 

PROVIDER: S-EPMC6826514 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature