Outcome of biological therapies in chronic antibiotic-refractory pouchitis: A retrospective single-centre experience.

ABSTRACT:

Background

In limited retrospective series, infliximab, adalimumab and vedolizumab have demonstrated efficacy in chronic antibiotic-refractory pouchitis. Here, we report single-centre data of all biological therapies in refractory pouchitis.

Methods

We retrospectively assessed all records from patients with ulcerative colitis and ileal pouch -anal anastomosis who received infliximab, adalimumab or vedolizumab for pouchitis. Clinically relevant remission, defined as a modified Pouchitis Disease Activity Index <5 and a reduction of modified Pouchitis Disease Activity Index ≥2 points from baseline, was assessed at week 14.

Results

Thirty-three unique patients were identified. Prior to colectomy, patients had been exposed to cyclosporine (n = 14), infliximab (n<

SUBMITTER: Verstockt B 

PROVIDER: S-EPMC6826521 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature