Non-Random Distribution of Reciprocal Translocation Breakpoints in the Pig Genome.

ABSTRACT: Balanced chromosome rearrangements are one of the main etiological factors contributing to hypoprolificacy in the domestic pig. Amongst domestic animals, the pig is considered to have the highest prevalence of chromosome rearrangements. To date over 200 unique chromosome rearrangements have been identified. The factors predisposing pigs to chromosome rearrangements, however, remain poorly understood. Nevertheless, here we provide empirical evidence which sustains the notion that there is a non-random distribution of chromosomal rearrangement breakpoints in the pig genome. We sought to establish if there are structural chromosome factors near which rearrangement breakpoints preferentially occur. The distribution of rearrangement breakpoints was analyzed across three level, chromosomes, chro

SUBMITTER: Donaldson B 

PROVIDER: S-EPMC6826608 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature