FADD in Cancer: Mechanisms of Altered Expression and Function, and Clinical Implications.

ABSTRACT: FADD was initially described as an adaptor molecule for death receptor-mediated apoptosis, but subsequently it has been implicated in nonapoptotic cellular processes such as proliferation and cell cycle control. During the last decade, FADD has been shown to play a pivotal role in most of the signalosome complexes, such as the necroptosome and the inflammasome. Interestingly, various mechanisms involved in regulating FADD functions have been identified, essentially posttranslational modifications and secretion. All these aspects have been thoroughly addressed in previous reviews. However, FADD implication in cancer is complex, due to pleiotropic effects. It has been reported either as anti- or protumorigenic, depending on the cell type. Regulation of FADD expression in cancer is a complex

SUBMITTER: Marin-Rubio JL 

PROVIDER: S-EPMC6826683 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature