Coding RNA Sequencing of Equine Endometrium during Maternal Recognition of Pregnancy.

ABSTRACT: Equine maternal recognition of pregnancy (MRP) is a process whose signal remains unknown. During MRP the conceptus and endometrium communicate to attenuate prostaglandin F_2α (PGF) secretion, sparing the corpus luteum and maintaining progesterone production. Recognition of a mobile conceptus by the endometrium is critical by days 14-16 post-ovulation (PO), when endometrium produces PGF, initiating luteolysis. The objective of this study was to evaluate endometrial gene expression changes based upon pregnancy status via RNA sequencing. This experiment utilized a cross-over design with each mare serving as both a pregnant and non-mated control on days nine, 11, and 13 PO (n = 3/status/day). Mares were randomly assigned to collection day and pregnancy confirmed by terminal ut

SUBMITTER: Klohonatz KM 

PROVIDER: S-EPMC6826732 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature