STAT3 and STAT5 Targeting for Simultaneous Management of Melanoma and Autoimmune Diseases.

ABSTRACT: Melanoma is a skin cancer which can become metastatic, drug-refractory, and lethal if managed late or inappropriately. An increasing number of melanoma patients exhibits autoimmune diseases, either as pre-existing conditions or as sequelae of immune-based anti-melanoma therapies, which complicate patient management and raise the need for more personalized treatments. STAT3 and/or STAT5 cascades are commonly activated during melanoma progression and mediate the metastatic effects of key oncogenic factors. Deactivation of these cascades enhances antitumor-immune responses, is efficient against metastatic melanoma in the preclinical setting and emerges as a promising targeting strategy, especially for patients resistant to immunotherapies. In the light of the recent realization that cancer an

SUBMITTER: Logotheti S 

PROVIDER: S-EPMC6826843 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature