Symbol Digit Modalities Test: A valid clinical trial endpoint for measuring cognition in multiple sclerosis.

ABSTRACT:

Background

The need for more robust outcomes in multiple sclerosis (MS) clinical trials has been a main priority of the field for decades. Dissatisfaction with existing measures has led to several consensus meetings and initiatives over the past few decades in hopes of defining and gaining acceptance of measures that are valid, reliable, sensitive to change and progression, and most importantly, relevant to those living with MS. The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) was formed for this purpose.

Objective

The objective of this paper is to describe the results of the MSOAC plan to obtain qualification for a cognitive performance measure that meets these requirements.

Methods

Using data from 14 MS disease-modifying registration trials, we complete

SUBMITTER: Strober L 

PROVIDER: S-EPMC6826875 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature