Effect of Antioxidant Supplementation on the Sperm Proteome of Idiopathic Infertile Men.

ABSTRACT: Antioxidant supplementation in idiopathic male infertility has a beneficial effect on semen parameters. However, the molecular mechanism behind this effect has not been reported. The objective of this study was to evaluate the sperm proteome of idiopathic infertile men pre- and post-antioxidant supplementation. Idiopathic infertile men were provided with oral antioxidant supplementation once daily for a period of 6 months. Of the 379 differentially expressed proteins (DEPs) between pre- and post-antioxidant treatment patients, the majority of the proteins (n = 274) were overexpressed following antioxidant treatment. Bioinformatic analysis revealed the activation of oxidative phosphorylation pathway and upregulation of key proteins involved in spermatogenesis, sperm maturation, bindi

SUBMITTER: Agarwal A 

PROVIDER: S-EPMC6827009 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature