Flow-metabolism uncoupling in patients with asymptomatic unilateral carotid artery stenosis assessed by multi-modal magnetic resonance imaging.

ABSTRACT: Oxygen extraction (OEF), oxidative metabolism (CMRO₂), and blood flow (CBF) in the brain, as well as the coupling between CMRO₂ and CBF due to cerebral autoregulation are fundamental to brain's health. We used a clinically feasible MRI protocol to assess impairments of these parameters in the perfusion territories of stenosed carotid arteries. Twenty-nine patients with unilateral high-grade carotid stenosis and thirty age-matched healthy controls underwent multi-modal MRI scans. Pseudo-continuous arterial spin labeling (pCASL) yielded absolute CBF, whereas multi-parametric quantitative blood oxygenation level dependent (mqBOLD) modeling allowed imaging of relative OEF and CMRO₂. Both CBF and CMRO₂ were significantly reduced in the stenosed territ

SUBMITTER: Gottler J 

PROVIDER: S-EPMC6827123 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature