Experimental ischemic stroke induces long-term T cell activation in the brain.

ABSTRACT: Mounting evidence has demonstrated that both innate and adaptive immune cells infiltrate into the brain after ischemic stroke. T cell invasion has been found in the ischemic region up to one month post experimental ischemic stroke and has been shown to persist for years in stroke patients. However, the function and phenotypic characteristics of the brain invading T cells after ischemic stroke have not been investigated. In the current study, we determined the function of brain invading T cells in the acute and chronic phase following experimental ischemic stroke induced by transient middle cerebral artery occlusion. We observed a significant increase of CD4⁺ and CD8⁺ T cells presented in the peri-infarct area at up to one month after experimental ischemic stroke. The

SUBMITTER: Xie L 

PROVIDER: S-EPMC6827125 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature