Hybrid ¹⁸F-FDG-PET/MRI Measurement of Standardized Uptake Value Coupled with Yin Yang 1 Signature in Metastatic Breast Cancer. A Preliminary Study.

ABSTRACT:

Purpose

Detection of breast cancer (BC) metastasis at the early stage is important for the assessment of BC progression status. Image analysis represents a valuable tool for the management of oncological patients. Our preliminary study combined imaging parameters from hybrid ¹⁸F-FDG-PET/MRI and the expression level of the transcriptional factor Yin Yang 1 (YY1) for the detection of early metastases.

Methods

The study enrolled suspected n = 217 BC patients that underwent ¹⁸F-FDG-PET/MRI scans. The analysis retrospectively included n = 55 subjects. n = 40 were BC patients and n = 15 imaging-negative female individuals were healthy subjects (HS). Standard radiomics parameters were extracted from PET/MRI image. RNA was obtained from peripheral blood mononuc

SUBMITTER: Schiano C 

PROVIDER: S-EPMC6827137 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature