Transcriptomic Signatures of Experimental Alkaloid Consumption in a Poison Frog.

ABSTRACT: In the anuran family Dendrobatidae, aposematic species obtain their toxic or unpalatable alkaloids from dietary sources, a process known as sequestering. To understand how toxicity evolved in this family, it is paramount to elucidate the pathways of alkaloid processing (absorption, metabolism, and sequestering). Here, we used an exploratory skin gene expression experiment in which captive-bred dendrobatids were fed alkaloids. Most of these experiments were performed with Dendrobates tinctorius, but some trials were performed with D. auratus, D. leucomelas and Allobates femoralis to explore whether other dendrobatids would show similar patterns of gene expression. We found a consistent pattern of up-regulation of genes related to muscle and mitochondrial processe

SUBMITTER: Sanchez E 

PROVIDER: S-EPMC6827147 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature