Genetic regulation of gene expression and splicing during a 10-year period of human aging.

ABSTRACT:

Background

Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there has been no long-term, longitudinal characterization of these molecular changes, especially in older age.

Results

We perform RNA sequencing in whole blood from the same individuals at ages 70 and 80 to quantify how gene expression, alternative splicing, and their genetic regulation are altered during this 10-year period of advanced aging at a population and individual level. We observe that individuals are more similar to their own expression profiles later in life than profiles of other individuals their own age. We identify 1291 and 294

SUBMITTER: Balliu B 

PROVIDER: S-EPMC6827221 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature