Maintenance therapy for recurrent epithelial ovarian cancer: current therapies and future perspectives - a review.

ABSTRACT: Epithelial ovarian cancer (EOC) is usually diagnosed late at an advanced stage. Though EOC initially responds to treatment, the recurrence rate is pretty high. The efficacy of different targeted therapies reduces with each recurrence. Hence there is need of effective maintenance therapy in recurrent EOC. Recently, polyADP-ribose polymerase (PARP) inhibitors (PARPi) have been approved both for initial treatment of EOC and as its maintenance treatment. PARPi have also been found to act regardless of BRCA status or homologous recombination (HR) deficiency. Several trials testing PARPi early in maintenance therapy are in progress and their results will shed light on the optimal timing of maintenance therapy that gives the most benefit with least toxicity. Right patient selection for maintenanc

SUBMITTER: Gupta S 

PROVIDER: S-EPMC6827246 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature