A Na⁺ leak channel cloned from Trichoplax adhaerens extends extracellular pH and Ca²⁺ sensing for the DEG/ENaC family close to the base of Metazoa.

ABSTRACT: Acid-sensitive ion channels belonging to the degenerin/epithelial sodium channel (DEG/ENaC) family activate in response to extracellular protons and are considered unique to deuterostomes. However, sensitivity to pH/protons is more widespread, where, for example, human ENaC Na⁺ leak channels are potentiated and mouse BASIC and Caenorhabditis elegans ACD-1 Na⁺ leak channels are blocked by extracellular protons. For many DEG/ENaC channels, extracellular Ca²⁺ ions modulate gating, and in some cases, the binding of protons and Ca²⁺ is interdependent. Here, we functionally characterize a DEG/ENaC channel from the early-diverging animal Trichoplax adhaerens, TadNaC6, that conducts Na⁺-selective leak currents in vitro<

SUBMITTER: Elkhatib W 

PROVIDER: S-EPMC6827283 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature