The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties.

ABSTRACT: Herpesviruses can rewire cellular signaling in host cells by expressing viral G protein-coupled receptors (GPCRs). These viral receptors exhibit homology to human chemokine receptors, but some display constitutive activity and promiscuous G protein coupling. Human cytomegalovirus (HCMV) has been detected in multiple cancers, including glioblastoma, and its genome encodes four GPCRs. One of these receptors, US28, is expressed in glioblastoma and possesses constitutive activity and oncomodulatory properties. UL33, another HCMV-encoded GPCR, also displays constitutive signaling via Gα_q, Gα_i, and Gα_s proteins. However, little is known about the nature and functional effects of UL33-driven signaling. Here, we assessed UL33's signaling repertoire and oncomodulato

SUBMITTER: van Senten JR 

PROVIDER: S-EPMC6827316 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature