Tranexamic Acid in Orthopaedic Trauma Surgery: A Meta-Analysis.

ABSTRACT:

Aim

To systematically review and quantify the efficacy of tranexamic acid (TXA) use in reducing the risk of receiving a blood transfusion in patients undergoing orthopaedic trauma surgery, in reducing blood loss, and risk of thromboembolic events.

Methods

A systematic literature search was performed using MEDLINE, Embase, ClinicalTrials.gov, and conference proceeding abstracts from 2014 to 2016. A minimum of 2 reviewers screened each study and graded quality. The primary outcome measure was the risk of receiving a blood transfusion in the TXA group versus control. A meta-analysis was performed to construct a combined odds ratio (OR) of receiving a blood transfusion, mean difference (MD) of blood loss, and OR of thromboembolic events.

Results

Twelve studies were includ

SUBMITTER: Gausden EB 

PROVIDER: S-EPMC6827340 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature