Comparison of the Full Distribution of Fitness Effects of New Amino Acid Mutations Across Great Apes.

ABSTRACT: The distribution of fitness effects (DFE) is central to many questions in evolutionary biology. However, little is known about the differences in DFE between closely related species. We use >9000 coding genes orthologous one-to-one across great apes, gibbons, and macaques to assess the stability of the DFE across great apes. We use the unfolded site frequency spectrum of polymorphic mutations (n = 8 haploid chromosomes per population) to estimate the DFE. We find that the shape of the deleterious DFE is strikingly similar across great apes. We confirm that effective population size (N_e ) is a strong predictor of the strength of negative selection, consistent with the nearly neutral theory. However, we also find that the strength of negative selection varies more th

SUBMITTER: Castellano D 

PROVIDER: S-EPMC6827385 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature