Impact and predictors of positive response to desensitization in pediatric heart transplant candidates.

ABSTRACT:

Background

Desensitization, the process of reducing anti-human leukocyte antigen (HLA) antibodies in sensitized patients awaiting heart transplantation (HT), has unclear efficacy in pediatric HT candidates.

Methods

Pediatric HT candidates listed at our institution between January 1, 2013 and June 30, 2018 were retrospectively evaluated. Sensitization was defined as the calculated panel reactive antibody (cPRA) ≥ 10% with ≥ 1 a strong positive antibody. The desensitization response was defined as a ≥ 25% reduction in the mean fluorescence intensity (MFI) for ≥ 90% of the strong positive antibodies on follow-up panel reactive antibody (PRA) testing before waitlist removal, HT, or death (data available for 13 patients).

Results

The HT candidates were categorized as sensi

SUBMITTER: Edwards JJ 

PROVIDER: S-EPMC6827717 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature