Dual pathway for metabolic engineering of Escherichia coli to produce the highly valuable hydroxytyrosol.

ABSTRACT: One of the most abundant phenolic compounds traced in olive tissues is hydroxytyrosol (HT), a molecule that has been attributed with a pile of beneficial effects, well documented by many epidemiological studies and thus adding value to products containing it. Strong antioxidant capacity and protection from cancer are only some of its exceptional features making it ideal as a potential supplement or preservative to be employed in the nutraceutical, agrochemical, cosmeceutical, and food industry. The HT biosynthetic pathway in plants (e.g. olive fruit tissues) is not well apprehended yet. In this contribution we employed a metabolic engineering strategy by constructing a dual pathway introduced in Escherichia coli and proofing its significant functionality leading it to produce HT. Our prima

SUBMITTER: Trantas E 

PROVIDER: S-EPMC6828502 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature