The Delta-Subunit Selective GABA _A Receptor Modulator, DS2, Improves Stroke Recovery via an Anti-inflammatory Mechanism.

ABSTRACT: Inflammatory processes are known to contribute to tissue damage in the central nervous system (CNS) across a broad range of neurological conditions, including stroke. Gamma amino butyric acid (GABA), the main inhibitory neurotransmitter in the CNS, has been implicated in modulating peripheral immune responses by acting on GABA _A receptors on antigen-presenting cells and lymphocytes. Here, we investigated the effects and mechanism of action of the delta-selective compound, DS2, to improve stroke recovery and modulate inflammation. We report a decrease in nuclear factor (NF)-κB activation in innate immune cells over a concentration range in vitro. Following a photochemically induced motor cortex stroke, treatment with DS2 at 0.1 mg/kg from 1 h post-stroke significant

SUBMITTER: Neumann S 

PROVIDER: S-EPMC6828610 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature