Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation.

ABSTRACT: In advanced inflammatory disease, microvascular thrombosis leads to the interruption of blood supply and provokes ischemic tissue injury. Recently, intravascularly adherent leukocytes have been reported to shape the blood flow in their immediate vascular environment. Whether these rheological effects are relevant for microvascular thrombogenesis remains elusive. Employing multi-channel in vivo microscopy, analyses in microfluidic devices, and computational modeling, we identified a previously unanticipated role of leukocytes for microvascular clot formation in inflamed tissue. For this purpose, neutrophils adhere at distinct sites in the microvasculature where these immune cells effectively promote thrombosis by shaping the rheological environment for platelet aggregation. In contrast to l

SUBMITTER: Puhr-Westerheide D 

PROVIDER: S-EPMC6828708 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature