Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.

ABSTRACT: As an immune checkpoint, Tim-3 plays roles in the regulation of both adaptive and innate immune cells including macrophages and is greatly involved in chronic liver diseases. However, the precise roles of Tim-3 in nonalcoholic steatohepatitis (NASH) remain unstated. In the current study, we analyzed Tim-3 expression on different subpopulations of liver macrophages and further investigated the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice. The results of flow cytometry demonstrated the significantly increased expression of Tim-3 on all detected liver macrophage subsets in MCD mice, including F4/80⁺CD11b⁺, F4/80⁺CD68⁺, and F4/80⁺CD169⁺ macrophages. Remarkably,

SUBMITTER: Du X 

PROVIDER: S-EPMC6828758 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature