Distributed slow-wave dynamics during sleep predict memory consolidation and its impairment in schizophrenia.

ABSTRACT: The slow waves (SW) of non-rapid eye movement (NREM) sleep reflect neocortical components of network activity during sleep-dependent information processing; their disruption may therefore impair memory consolidation. Here, we quantify sleep-dependent consolidation of motor sequence memory, alongside sleep EEG-derived SW properties and synchronisation, and SW-spindle coupling in 21 patients suffering from schizophrenia and 19 healthy volunteers. Impaired memory consolidation in patients culminated in an overnight improvement in motor sequence task performance of only 1.6%, compared with 15% in controls. During sleep after learning, SW amplitudes and densities were comparable in healthy controls and patients. However, healthy controls showed a significant 45% increase in frontal-to-occipital

SUBMITTER: Bartsch U 

PROVIDER: S-EPMC6828759 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature