β-catenin regulates the formation of multiple nephron segments in the mouse kidney.

ABSTRACT: The nephron is composed of distinct segments that perform unique physiological functions. Little is known about how multipotent nephron progenitor cells differentiate into different nephron segments. It is well known that β-catenin signaling regulates the maintenance and commitment of mesenchymal nephron progenitors during kidney development. However, it is not fully understood how it regulates nephron segmentation after nephron progenitors undergo mesenchymal-to-epithelial transition. To address this, we performed β-catenin loss-of-function and gain-of-function studies in epithelial nephron progenitors in the mouse kidney. Consistent with a previous report, the formation of the renal corpuscle was defective in the absence of β-catenin. Interestingly, we found that epithelial nephron proge

SUBMITTER: Deacon P 

PROVIDER: S-EPMC6828815 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature