Comparative genomic and functional analysis of Akkermansia muciniphila and closely related species.

ABSTRACT:

Background

Akkermansia muciniphila is an important bacterium that resides on the mucus layer of the intestinal tract. Akkermansia muciniphila has a high abundance in human feces and plays an important role in human health.

Objective

In this article, 23 whole genome sequences of the Akkermansia genus were comparatively studied.

Methods

Phylogenetic trees were constructed with three methods: All amino acid sequences of each strain were used to construct the first phylogenetic tree using the web server of Composition Vector Tree Version 3. The matrix of Genome-to-Genome Distances which were obtained from GGDC 2.0 was used to construct the second phylogenetic tree using FastME. The concatenated single-copy core gene-based phylogenetic tree was generated through MEGA. The

SUBMITTER: Xing J 

PROVIDER: S-EPMC6828834 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature