Intrinsic Functional Connectivity is Organized as Three Interdependent Gradients.

ABSTRACT: The intrinsic functional architecture of the brain supports moment-to-moment maintenance of an internal model of the world. We hypothesized and found three interdependent architectural gradients underlying the organization of intrinsic functional connectivity within the human cerebral cortex. We used resting state fMRI data from two samples of healthy young adults (N's = 280 and 270) to generate functional connectivity maps of 109 seeds culled from published research, estimated their pairwise similarities, and multidimensionally scaled the resulting similarity matrix. We discovered an optimal three-dimensional solution, accounting for 98% of the variance within the similarity matrix. The three dimensions corresponded to three gradients, which spatially correlate with two functional feature

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6828953 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature