Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors.

ABSTRACT:

Introduction

Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors.

Methods

We evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes.

Results

PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vasc

SUBMITTER: Lam BYK 

PROVIDER: S-EPMC6829102 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature