Molecular Profiling of the Drosophila Antenna Reveals Conserved Genes Underlying Olfaction in Insects.

ABSTRACT: Repellent odors are widely used to prevent insect-borne diseases, making it imperative to identify the conserved molecular underpinnings of their olfactory systems. Currently, little is known about the molecules supporting odor signaling beyond the odor receptors themselves. Most known molecules function in one of two classes of olfactory sensilla, single-walled or double-walled, which have differing morphology and odor response profiles. Here, we took two approaches to discover novel genes that contribute to insect olfaction in the periphery. We transcriptionally profiled Drosophila melanogaster amos mutants that lack trichoid and basiconic sensilla, the single-walled sensilla in this species. This revealed 187 genes whose expression is enriched in these sensilla, including pickpoc

SUBMITTER: Mohapatra P 

PROVIDER: S-EPMC6829134 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature