Systemic Inflammation Precedes Microalbuminuria in Diabetes.

ABSTRACT:

Aim

The aim of the case-control study was to investigate if serum biomarkers indicative of vascular inflammation and endothelial dysfunction can predict the development of microalbuminuria in patients with diabetes mellitus type 2.

Methods

Among participants enrolled in the ROADMAP (Randomized Olmesartan And Diabetes MicroAlbuminuria Prevention) and observational follow-up (OFU) studies, a panel of 15 serum biomarkers was quantified from samples obtained at initiation of the study and tested for associations with the development of new-onset microalbuminuria during follow-up. A case-control study was conducted with inclusion of 172 patients with microalbuminuria and 188 matched controls. Nonparametric inferential, nonlinear regression, mediation, and bootstrapping statistica

SUBMITTER: Scurt FG 

PROVIDER: S-EPMC6829192 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature