Neglog: Homology-Based Negative Data Sampling Method for Genome-Scale Reconstruction of Human Protein-Protein Interaction Networks.

ABSTRACT: Rapid reconstruction of genome-scale protein-protein interaction (PPI) networks is instrumental in understanding the cellular processes and disease pathogenesis and drug reactions. However, lack of experimentally verified negative data (i.e., pairs of proteins that do not interact) is still a major issue that needs to be properly addressed in computational modeling. In this study, we take advantage of the very limited experimentally verified negative data from Negatome to infer more negative data for computational modeling. We assume that the paralogs or orthologs of two non-interacting proteins also do not interact with high probability. We coin an assumption as "Neglog" this assumption is to some extent supported by paralogous/orthologous structure conservation. To reduce the risk of bia

SUBMITTER: Mei S 

PROVIDER: S-EPMC6829266 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature