Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.

ABSTRACT:

Background

Identifying reliable predictors of long-term weight loss (LTWL) could lead to improved weight management.

Objective

To identify some predictors of LTWL.

Design

The DPP (Diabetes Prevention Program) was a randomized controlled trial that compared weight loss with metformin, intensive lifestyle intervention (ILS), or placebo. Its Outcomes Study (DPPOS) observed patients after the masked treatment phase ended. (ClinicalTrials.gov: NCT00004992 and NCT00038727).

Setting

27 DPP and DPPOS clinics.

Participants

Of the 3234 randomly assigned participants, 1066 lost at least 5% of baseline weight in the first year and were followed for 15 years.

Measurements

Treatment assignment, personal characteristics, and weight.

Results

After 1 year,

SUBMITTER: Apolzan JW 

PROVIDER: S-EPMC6829283 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature